Using a murine HCC model induced by diethylnitrosamine (DEN), CD4+ T cells have been found to prevent tumor initiation and mediate the clearance of premalignant hepatocytes10

Since both Zero? and ONOO? can diffuse to adjacent cells through membrane difference or permeation junctions, the creation of both these substances in adjacent endothelial cells, which make NO? for a lot more than 100 min but ONOO continuously? for under 0 transiently