Small molecule KDM4s inhibitors As Anti-Cancer Chemotherapeutics

KDM4s inhibitor

Category: p56lck

p56lck

In the phase III ULTIMATE trial,19 166 patients with advanced NSCLCs progressing after first- or second-line therapy were randomized to receive weekly the paclitaxelCBVZ combination compared to docetaxel; progression-free survival (PFS) was significantly longer for the former group but overall survival (OS) was comparable for the two groups

Jan 29, 2023 admin

In the phase III ULTIMATE trial,19 166 patients with advanced NSCLCs progressing after first- or second-line therapy were randomized to…

p56lck

The gradually progressive phenotype from the KO mice finally yielding in mild (lysosomal) dysfunction and finally cell death within a subset of neurons suggests a mechanism when a primary (genetic) predisposition establishes disease starting point and variants in TMEM106B resulting in altered levels or function become another hit, where the span of the condition is modulated

Apr 23, 2022 admin

The gradually progressive phenotype from the KO mice finally yielding in mild (lysosomal) dysfunction and finally cell death within a…

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