Author: admin

The gradually progressive phenotype from the KO mice finally yielding in mild (lysosomal) dysfunction and finally cell death within a subset of neurons suggests a mechanism when a primary (genetic) predisposition establishes disease starting point and variants in TMEM106B resulting in altered levels or function become another hit, where the span of the condition is modulated

The gradually progressive phenotype from the KO mice finally yielding in mild (lysosomal) dysfunction and finally cell death within a…